RFX7

Across TCGA patient cohorts, RFX7 mutation is significantly associated with the RNA expression of many other genes, with 6,891 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFX7-associated genes across cancer lineages are R3HCC1, ATP5F1B, and COX7A2. Each is linked with RFX7 in more than 2 cancer types. Because this analysis shows association rather than direction, both RFX7-to-partner and partner-to-RFX7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, R3HCC1 grouped by RFX7-low versus RFX7-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX7→partner) and Y-score (partner→RFX7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	R3HCC1 →	+0.514	+3.381	.003	.004	3	3
UCEC	ATP5F1B →	+0.447	+1.593	<.001	<.001	3	3
UCEC	COX7A2 →	+0.277	+1.516	<.001	.002	3	3
UCEC	BCL2L12 →	+0.382	+2.000	<.001	<.001	3	3
UCEC	AOC2 →	+0.906	+1.713	<.001	<.001	3	3
UCEC	ESCO2 →	+0.730	+2.169	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,891 associations by consensus.

R3HCC1 by RFX7 expression — COAD

Explore this box plot interactively →