Across TCGA cell cohorts, RFX6 mutation is significantly associated with the RNA expression of many other genes, with 356 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RFX6-associated genes across cancer lineages are OR4E1, RLN3, and C18orf21. Each is linked with RFX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFX6-to-partner and partner-to-RFX6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX6→partner) and Y-score (partner→RFX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR4E1 →	+0.090	+4.196	<.001	.006	3	2
STOMACH	RLN3 →	+0.205	+4.285	<.001	.007	3	2
LARGE_INTESTINE	C18orf21 →	+0.512	+2.850	.005	<.001	3	2
SKIN	CD1C →	+0.046	+3.054	<.001	.001	3	1
SKIN	PRY →	+0.501	+3.179	.002	.001	3	1
SKIN	PRORY →	+0.429	+3.009	.003	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 356 associations by consensus.

Exploration

RFX6 survival (RNA) · tumor vs normal (RNA) · all RFX6 data types