RFX2

Across TCGA cell cohorts, RFX2 mutation is significantly associated with the RNA expression of many other genes, with 103 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RFX2-associated genes across cancer lineages are NEU2, FAM205C, and OR1J2. Each is linked with RFX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFX2-to-partner and partner-to-RFX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NEU2 grouped by RFX2-low versus RFX2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX2→partner) and Y-score (partner→RFX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NEU2 →	+0.061	+3.882	<.001	.004	3	1
SOFT_TISSUE	FAM205C →	+0.075	+4.515	<.001	<.001	3	1
SOFT_TISSUE	OR1J2 →	+0.047	+3.635	<.001	.007	3	1
SOFT_TISSUE	BHLHA9 →	+0.022	+4.392	<.001	.004	3	1
BREAST	KLRF2 →	+0.047	+4.781	<.001	.003	3	1
BREAST	NOX3 →	+0.924	+4.421	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 103 associations by consensus.

NEU2 by RFX2 expression — SOFT_TISSUE

Explore this box plot interactively →