RFX1

Across TCGA patient cohorts, RFX1 protein abundance is significantly associated with the protein abundance of many other proteins, with 31,391 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible RFX1-associated proteins across cancer lineages are RBBP5, DDX17, and RBM12. Each is linked with RFX1 in more than 8 cancer types. Because this analysis shows association rather than direction, both RFX1-to-partner and partner-to-RFX1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, RFX1 versus RBBP5 in LSCC, with a Pearson correlation of 0.55.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (RFX1→partner) and Y-score (partner→RFX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RBBP5 →	+0.296	+0.225	<.001	<.001	3	9
HNSC	DDX17 →	+0.279	+0.219	<.001	<.001	3	9
OV	RBM12 →	+0.269	+0.333	<.001	<.001	3	8
GBM	POLR2A →	+0.205	+0.265	<.001	<.001	3	8
HNSC	RPRD2 →	+0.252	+0.159	<.001	<.001	3	8
OV	SF3B3 →	+0.197	+0.225	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 31,391 associations by consensus.

RFX1 vs RBBP5 — LSCC

Explore this scatter interactively →