RFTN1

Across TCGA patient cohorts, RFTN1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFTN1-associated genes across cancer lineages are ATM, mTOR_pS2448, and Notch1. Each is linked with RFTN1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RFTN1-to-partner and partner-to-RFTN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by RFTN1-low versus RFTN1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFTN1→partner) and Y-score (partner→RFTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.430	-2.687	.003	.005	3	3
UCEC	mTOR_pS2448 →	-0.113	-1.986	.019	.008	3	2
UCEC	Notch1 →	+0.178	+2.009	<.001	.001	3	2
COAD	p21 →	+0.229	+3.212	.034	.009	3	2
UCEC	PDCD4 →	-0.388	-2.584	.011	.010	3	2
UCEC	PI3K-p110-a →	-0.118	-2.000	.039	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ATM by RFTN1 expression — UCEC

Explore this box plot interactively →