RFTN1

Across TCGA pan-cancer cohorts, RFTN1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RFTN1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RFTN1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RFTN1 is over-expressed in tumor, although a few such as LUSC and LUAD show the opposite, repressed pattern.

HNSC, KIRC, and LUSC are the cancer types where RFTN1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RFTN1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	IV	+2.059	<.001	11	view →
KIRC	Female	All	+1.358	<.001	11	view →
LUSC	Female	All	−2.106	<.001	9	view →
LUAD	Female	III,IV	−1.081	<.001	9	view →
KICH	Female	All	−1.821	<.001	8	view →
THCA	All	II,III,IV	−0.726	<.001	8	view →
STAD	All	II,III,IV	+1.107	<.001	7	view →
UCEC	All	All	−2.565	<.001	6	view →
BRCA	All	II,III,IV	−0.610	<.001	6	view →
ESCA	All	All	+1.113	.008	2	view →
KIRP	All	All	−0.777	.001	2	view →
PRAD	All	All	−0.408	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RFTN1–HNSC

Open the HNSC breakdown →