RFTN1

Across TCGA cell cohorts, RFTN1 mutation is significantly associated with the RNA expression of many other genes, with 19 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RFTN1-associated genes across cancer lineages are SIX6, SLC17A2, and SLC22A8. Each is linked with RFTN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFTN1-to-partner and partner-to-RFTN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIX6 grouped by RFTN1-low versus RFTN1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFTN1→partner) and Y-score (partner→RFTN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	SIX6 →	+0.005	+3.285	<.001	.009	3	2
BLOOD_Myeloma	SLC17A2 →	+0.009	+3.285	<.001	.009	3	1
BLOOD_Myeloma	SLC22A8 →	+0.010	+3.754	<.001	.002	3	1
BLOOD_Myeloma	SPRR1B →	+0.155	+3.514	<.001	.008	3	1
BLOOD_Myeloma	CST9 →	+0.016	+3.754	<.001	.002	3	1
BLOOD_Myeloma	TENT5D →	+0.020	+4.700	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

SIX6 by RFTN1 expression — BLOOD_Myeloma

Explore this box plot interactively →