RFPL4B

Across TCGA patient cohorts, RFPL4B mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFPL4B-associated genes across cancer lineages are Caspase-7-cleavedD198, EGFR_pY1068, and FOXO3a_pS318_S321. Each is linked with RFPL4B in more than 2 cancer types. Because this analysis shows association rather than direction, both RFPL4B-to-partner and partner-to-RFPL4B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by RFPL4B-low versus RFPL4B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFPL4B→partner) and Y-score (partner→RFPL4B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.530	+1.765	.017	.014	3	3
UCEC	EGFR_pY1068 →	-0.220	-1.765	.019	.014	3	2
SKCM	FOXO3a_pS318_S321 →	-0.194	-2.982	.012	.036	3	2
UCEC	INPP4B →	-0.266	-2.459	.028	.018	3	2
UCEC	JNK_pT183_Y185 →	-0.211	-2.156	<.001	.003	3	2
UCEC	PDCD4 →	-0.494	-2.312	.005	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

Caspase-7-cleavedD198 by RFPL4B expression — UCEC

Explore this box plot interactively →