RFPL4AL1

Across TCGA pan-cancer cohorts, RFPL4AL1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of RFPL4AL1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where RFPL4AL1 RNA is repressed in tumor relative to normal tissue. In most cancer types RFPL4AL1 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and READ are the cancer types where RFPL4AL1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RFPL4AL1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	−0.042	.008	5	view →
KICH	All	All	−0.017	.020	2	view →
READ	All	All	−0.088	.015	1	view →
KIRC	Male	II,III,IV	+0.037	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

RFPL4AL1–COAD

Open the COAD breakdown →