RFPL3

Across TCGA cell cohorts, RFPL3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible RFPL3-associated genes across cancer lineages are FAM90A26, TMEM202, and FAM47B. Each is linked with RFPL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFPL3-to-partner and partner-to-RFPL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FAM90A26 grouped by RFPL3-low versus RFPL3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFPL3→partner) and Y-score (partner→RFPL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	FAM90A26 →	+0.010	+4.409	<.001	.005	3	1
LUNG_NSCLC_LUAD	TMEM202 →	+0.033	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	FAM47B →	+0.013	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR8B4 →	+0.027	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

FAM90A26 by RFPL3 expression — BLOOD_Leukemia

Explore this box plot interactively →