Across TCGA pan-cancer cohorts, RFPL1S RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RFPL1S’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where RFPL1S RNA is repressed in tumor relative to normal tissue. In most cancer types RFPL1S is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.
THCA, COAD, and BRCA are the cancer types where RFPL1S tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RFPL1S RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.