RFPL1

Across TCGA patient cohorts, RFPL1 mutation is significantly associated with the RNA expression of many other genes, with 2,989 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFPL1-associated genes across cancer lineages are ATP13A1, TRMT2A, and MINAR2. Each is linked with RFPL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RFPL1-to-partner and partner-to-RFPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP13A1 grouped by RFPL1-low versus RFPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFPL1→partner) and Y-score (partner→RFPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP13A1 →	+0.403	+3.917	<.001	<.001	3	3
UCEC	TRMT2A →	+0.289	+1.694	.003	.003	3	3
READ	MINAR2 →	+0.083	+4.361	<.001	.006	3	2
READ	OR12D1 →	+0.104	+6.842	<.001	<.001	3	2
READ	MIR4797 →	+0.819	+5.054	<.001	.001	3	2
READ	BPNT2P →	+0.111	+5.681	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,989 associations by consensus.

ATP13A1 by RFPL1 expression — UCEC

Explore this box plot interactively →