RFPL1

Across TCGA pan-cancer cohorts, RFPL1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated RFPL1 data layer compared with 7 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RFPL1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated RFPL1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUSC show a favorable association.

HNSC, KIRC, and LUSC are the cancer types where RFPL1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.741	0.577	<.001	135	view →
KIRC	DFS	Tertile	All	0.652	0.834	.002	55	view →
LUSC	OS	Median	All	0.824	0.731	.003	54	view →
THYM	DFS	Quartile	All	0.723	0.951	.001	38	view →
UCEC	OS	Tertile	All	0.856	0.934	.006	36	view →
ACC	DFS	Quartile	All	0.238	0.640	.003	33	view →
THCA	OS	Tertile	IV	0.805	1.000	<.001	18	view →
SARC	DFS	Tertile	All	0.418	0.668	.001	16	view →
LIHC	DFS	Tertile	II,III,IV	0.727	0.360	.003	15	view →
BLCA	OS	Quartile	III,IV	0.637	0.506	.017	13	view →
PAAD	DFS	Tertile	All	0.392	0.239	.024	12	view →
GBM	OS	Tertile	All	0.267	0.465	.001	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

RFPL1–HNSC (OS)

Open the HNSC breakdown →