RFPL1

Across TCGA patient cohorts, RFPL1 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFPL1-associated genes across cancer lineages are Cyclin-B1, STAT3_pY705, and ASNS. Each is linked with RFPL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RFPL1-to-partner and partner-to-RFPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by RFPL1-low versus RFPL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFPL1→partner) and Y-score (partner→RFPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.550	+2.584	.004	.010	3	3
UCEC	STAT3_pY705 →	-0.420	-2.169	<.001	.002	3	2
UCEC	ASNS →	+0.311	+1.415	.013	.043	3	2
UCEC	Caveolin-1 →	-0.616	-2.584	.014	.010	3	2
SKCM	YB-1 →	-0.265	-3.169	.017	.019	3	1
UCEC	EGFR_pY1068 →	-0.220	-2.321	.011	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Cyclin-B1 by RFPL1 expression — UCEC

Explore this box plot interactively →