RFPL1

Across TCGA cell cohorts, RFPL1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RFPL1-associated genes across cancer lineages are OR10H5, TRIM51, and MCHR2. Each is linked with RFPL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFPL1-to-partner and partner-to-RFPL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10H5 grouped by RFPL1-low versus RFPL1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFPL1→partner) and Y-score (partner→RFPL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR10H5 →	+0.012	+4.977	<.001	.007	3	1
BLOOD_Leukemia	TRIM51 →	+0.042	+4.152	.004	.009	3	1
BLOOD_Leukemia	MCHR2 →	+0.034	+4.539	<.001	.007	3	1
BLOOD_Leukemia	ANGPTL5 →	+0.022	+4.276	.007	.007	3	1
BLOOD_Leukemia	KRTAP12-3 →	+0.087	+4.539	<.001	.007	3	1
BLOOD_Leukemia	TSPY8 →	+0.161	+4.409	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

OR10H5 by RFPL1 expression — SKIN

Explore this box plot interactively →