RFNG

Across TCGA patient cohorts, RFNG mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. COAD shows the largest number of these associations.

The most reproducible RFNG-associated genes across cancer lineages are IGKV2-38, KIR3DP1, and RNU6-278P. Each is linked with RFNG in more than 1 cancer types. Because this analysis shows association rather than direction, both RFNG-to-partner and partner-to-RFNG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGKV2-38 grouped by RFNG-low versus RFNG-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFNG→partner) and Y-score (partner→RFNG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IGKV2-38 →	+0.108	+7.731	<.001	.009	3	1
BRCA	KIR3DP1 →	+0.044	+8.055	<.001	.007	3	1
BRCA	RNU6-278P →	+0.232	+7.731	<.001	.009	3	1
BRCA	RPS29P26 →	+0.153	+8.055	<.001	.007	3	1
COAD	CST8 →	+0.297	+4.428	<.001	.002	3	1
COAD	KRTAP17-1 →	+0.398	+4.037	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

IGKV2-38 by RFNG expression — BRCA

Explore this box plot interactively →