RFLNA

Across TCGA pan-cancer cohorts, RFLNA mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RFLNA data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RFLNA mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated RFLNA expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and LUAD are the cancer types where RFLNA mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.853	0.564	.040	2	view →
UCEC	OS	Quartile	All	1.000	0.715	.040	2	view →
LUAD	DFS	Tertile	All	0.977	0.906	.035	1	view →
LSCC	OS	Median	All	0.767	1.000	.015	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RFLNA–HNSC (DFS)

Open the HNSC breakdown →