RFLNA

Across TCGA pan-cancer cohorts, RFLNA RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RFLNA’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where RFLNA RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RFLNA is over-expressed in tumor, although a few such as UCEC and READ show the opposite, repressed pattern.

LUAD, THCA, and LUSC are the cancer types where RFLNA tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RFLNA RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	II,III,IV	+2.083	<.001	9	view →
THCA	Female	All	+0.380	<.001	9	view →
LUSC	Male	II,III,IV	+1.914	<.001	8	view →
HNSC	Female	All	+1.201	.007	8	view →
BLCA	All	All	+0.891	.008	6	view →
LIHC	Female	All	+0.585	<.001	6	view →
UCEC	All	All	−1.066	.031	4	view →
READ	All	All	−1.527	.009	2	view →
CHOL	All	All	+1.195	.006	2	view →
STAD	All	IV	−2.976	.019	1	view →
COAD	Male	IV	−0.908	.045	1	view →
KICH	All	All	−0.471	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RFLNA–LUAD

Open the LUAD breakdown →