RFLNA

Across TCGA patient cohorts, RFLNA mutation is significantly associated with the RNA expression of many other genes, with 85 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFLNA-associated genes across cancer lineages are MTCYBP36, MIR6803, and RNA5SP414. Each is linked with RFLNA in more than 1 cancer types. Because this analysis shows association rather than direction, both RFLNA-to-partner and partner-to-RFLNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTCYBP36 grouped by RFLNA-low versus RFLNA-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFLNA→partner) and Y-score (partner→RFLNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MTCYBP36 →	+0.070	+7.108	<.001	<.001	3	2
LUAD	MIR6803 →	+0.367	+5.798	<.001	.003	3	2
UCEC	RNA5SP414 →	+0.875	+2.933	<.001	.006	3	1
UCEC	MIR7702 →	+0.415	+5.253	<.001	.001	3	1
HNSC	MIR6795 →	+0.438	+7.954	<.001	.008	3	1
SKCM	RN7SL446P →	+0.148	+4.513	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 85 associations by consensus.

MTCYBP36 by RFLNA expression — LUAD

Explore this box plot interactively →