RFLNA

Across TCGA patient cohorts, RFLNA mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible RFLNA-associated genes across cancer lineages are CD4+ Tcm and Th2 cells. Each is linked with RFLNA in more than 1 cancer types. Because this analysis shows association rather than direction, both RFLNA-to-partner and partner-to-RFLNA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD4+ Tcm grouped by RFLNA-low versus RFLNA-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFLNA→partner) and Y-score (partner→RFLNA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CD4+ Tcm →	+0.007	+5.468	<.001	.043	3	1
UCEC	Th2 cells →	+0.222	+3.000	.033	.037	1	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

CD4+ Tcm by RFLNA expression — HNSC

Explore this box plot interactively →