RFK

Across TCGA pan-cancer cohorts, RFK mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated RFK data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher RFK mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated RFK expression acts as an unfavorable survival marker, although some lineages such as UCEC and HNSC show a favorable association.

CCRCC, UCEC, and LSCC are the cancer types where RFK mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.613	0.871	.003	15	view →
UCEC	OS	Tertile	All	1.000	0.856	.018	10	view →
LSCC	DFS	Tertile	II,III,IV	0.762	0.963	.005	8	view →
COAD	DFS	Median	IV	0.493	0.944	.031	6	view →
LUAD	OS	Quartile	III,IV	0.328	0.925	.018	4	view →
HNSC	OS	Median	IV	0.834	0.632	.028	4	view →
PDAC	DFS	Quartile	All	0.785	0.601	.025	3	view →
GBM	OS	Tertile	All	0.939	0.705	.027	2	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

RFK–CCRCC (DFS)

Open the CCRCC breakdown →