RFK

Across TCGA pan-cancer cohorts, RFK RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of RFK’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where RFK RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RFK is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

LIHC, BRCA, and COAD are the cancer types where RFK tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RFK RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	All	+0.568	<.001	8	view →
BRCA	All	II,III,IV	+0.244	.002	6	view →
COAD	Female	All	−0.924	<.001	5	view →
LUAD	Male	II,III,IV	+0.964	<.001	4	view →
STAD	All	II,III,IV	+0.752	<.001	4	view →
ESCA	All	All	+1.004	.018	2	view →
CHOL	All	All	+0.972	.009	2	view →
PRAD	All	All	+0.395	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

RFK–LIHC

Open the LIHC breakdown →