RFK

Across TCGA patient cohorts, RFK mutation is significantly associated with the RNA expression of many other genes, with 397 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFK-associated genes across cancer lineages are RNA5SP48, RNU6-1243P, and RNU6-17P. Each is linked with RFK in more than 1 cancer types. Because this analysis shows association rather than direction, both RFK-to-partner and partner-to-RFK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP48 grouped by RFK-low versus RFK-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFK→partner) and Y-score (partner→RFK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP48 →	+0.384	+4.578	<.001	.008	3	1
HNSC	RNU6-1243P →	+0.263	+5.468	<.001	.002	3	1
HNSC	RNU6-17P →	+0.300	+5.608	<.001	.002	3	1
HNSC	RNA5SP158 →	+0.303	+5.221	<.001	.003	3	1
UCEC	GPR75-ASB3 →	+0.074	+2.631	.004	.008	3	1
HNSC	SRIP3 →	+0.196	+4.716	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 397 associations by consensus.

RNA5SP48 by RFK expression — HNSC

Explore this box plot interactively →