RFK

Across TCGA patient cohorts, RFK mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFK-associated genes across cancer lineages are Myosin-IIa, PDCD4, and Annexin-1. Each is linked with RFK in more than 1 cancer types. Because this analysis shows association rather than direction, both RFK-to-partner and partner-to-RFK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Myosin-IIa grouped by RFK-low versus RFK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFK→partner) and Y-score (partner→RFK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Myosin-IIa →	+0.261	+2.177	.007	.035	3	1
UCEC	PDCD4 →	-0.595	-2.990	.015	.036	3	1
UCEC	Annexin-1 →	+0.791	+3.321	.004	.010	3	1
UCEC	Shc_pY317 →	-0.292	-2.999	<.001	.035	3	1
UCEC	STAT3_pY705 →	-0.517	-2.999	<.001	.035	3	1
UCEC	Tuberin →	+0.393	+3.009	.005	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Myosin-IIa by RFK expression — UCEC

Explore this box plot interactively →