RFK

Across TCGA cell cohorts, RFK RNA expression is significantly associated with the go_rna of many other GO terms, with 3,583 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible RFK-associated GO terms across cancer lineages are Riboflavin metabolic process, Flavin-containing compound metabolic process, and Positive regulation of oxidoreductase activity. Each is linked with RFK in more than 19 cancer types. Because this analysis shows association rather than direction, both RFK-to-partner and partner-to-RFK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Riboflavin metabolic process grouped by RFK-low versus RFK-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RFK→partner) and Y-score (partner→RFK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Riboflavin metabolic process →	+0.263	+1.066	<.001	<.001	3	20
LUNG_NSCLC_LUSC	Flavin-containing compound metabolic process →	+0.287	+1.569	<.001	<.001	3	18
BLOOD_Lymphoma	Positive regulation of oxidoreductase activity →	+0.150	+1.049	<.001	<.001	3	10
URINARY_TRACT	Ribonucleoside monophosphate biosynthetic process →	+0.084	+1.012	.003	.008	2	11
LUNG_SCLC	Regulation of oxidoreductase activity →	+0.150	+0.985	<.001	<.001	3	10
SKIN	Proteasome regulatory particle assembly →	+0.110	+0.527	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,583 associations by consensus.

Riboflavin metabolic process by RFK expression — LUNG_SCLC

Explore this box plot interactively →