RFESD

Across TCGA patient cohorts, RFESD mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFESD-associated genes across cancer lineages are mTOR, Myosin-IIa_pS1943, and PDCD4. Each is linked with RFESD in more than 1 cancer types. Because this analysis shows association rather than direction, both RFESD-to-partner and partner-to-RFESD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR grouped by RFESD-low versus RFESD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFESD→partner) and Y-score (partner→RFESD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR →	-0.174	-2.321	.032	.035	3	1
UCEC	Myosin-IIa_pS1943 →	+0.210	+2.335	.043	.020	3	1
UCEC	PDCD4 →	-0.667	-2.321	.004	.035	3	1
UCEC	STAT3_pY705 →	-0.429	-2.999	.001	.035	3	1
UCEC	TIGAR →	+0.175	+2.348	.022	.019	3	1
UCEC	PCNA →	+0.353	+2.321	.001	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

mTOR by RFESD expression — UCEC

Explore this box plot interactively →