RFESD

Across TCGA pan-cancer cohorts, RFESD RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of RFESD’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where RFESD RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RFESD is over-expressed in tumor, although a few such as UCEC and THCA show the opposite, repressed pattern.

LIHC, UCEC, and THCA are the cancer types where RFESD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RFESD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	All	+0.347	<.001	8	view →
UCEC	All	All	−0.405	<.001	6	view →
THCA	Male	II,III,IV	−0.266	.006	5	view →
KICH	All	All	−0.547	<.001	4	view →
CHOL	Male	All	+0.333	<.001	4	view →
BRCA	All	III,IV	+0.224	.016	4	view →
LUAD	All	All	+0.195	<.001	3	view →
KIRP	Male	All	−0.234	.014	2	view →
STAD	Male	III,IV	−0.250	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

RFESD–LIHC

Open the LIHC breakdown →