RFC4

Across TCGA pan-cancer cohorts, RFC4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated RFC4 data layer compared with 29 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher RFC4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated RFC4 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where RFC4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.380	1.000	.008	51	view →
CCRCC	DFS	Median	III,IV	0.809	1.000	.012	29	view →
LUAD	DFS	Quartile	III,IV	1.000	0.415	.008	14	view →
LSCC	DFS	Tertile	II,III,IV	0.858	0.550	.019	11	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

RFC4–HNSC (OS)

Open the HNSC breakdown →