RFC4

Across TCGA patient cohorts, RFC4 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFC4-associated genes across cancer lineages are MEK1, S6_pS240_S244, and Src. Each is linked with RFC4 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFC4-to-partner and partner-to-RFC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by RFC4-low versus RFC4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFC4→partner) and Y-score (partner→RFC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.425	+3.000	.044	.036	3	1
UCEC	S6_pS240_S244 →	+0.512	+3.000	.029	.037	3	1
UCEC	Src →	-0.300	-3.000	.011	.037	3	1
UCEC	Chk2 →	-0.352	-3.000	.009	.036	3	1
UCEC	p27_pT198 →	+0.136	+3.000	.027	.037	2	1
UCEC	ATM →	-0.928	-3.000	<.001	.037	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MEK1 by RFC4 expression — UCEC

Explore this box plot interactively →