RFC4

Across TCGA cell cohorts, RFC4 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,143 significant associations in total. BONE shows the largest number of these associations.

The most reproducible RFC4-associated GO terms across cancer lineages are DNA replication, DNA-templated DNA replication, and DNA replication initiation. Each is linked with RFC4 in more than 19 cancer types. Because this analysis shows association rather than direction, both RFC4-to-partner and partner-to-RFC4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA replication grouped by RFC4-low versus RFC4-high in BLOOD_Myeloma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RFC4→partner) and Y-score (partner→RFC4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	DNA replication →	+0.102	+1.216	<.001	<.001	3	20
BONE	DNA-templated DNA replication →	+0.115	+0.847	<.001	.002	3	20
BONE	DNA replication initiation →	+0.199	+1.299	<.001	<.001	3	20
BONE	Replication fork processing →	+0.101	+0.790	<.001	.005	3	19
UPPER_AERODIGESTIVE_TRACT	DNA integrity checkpoint signaling →	+0.097	+1.517	<.001	<.001	3	19
PANCREAS	Mitotic DNA replication checkpoint signaling →	+0.171	+1.214	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,143 associations by consensus.

DNA replication by RFC4 expression — BLOOD_Myeloma

Explore this box plot interactively →