RFC2

Across TCGA patient cohorts, RFC2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RFC2-associated genes across cancer lineages are 14-3-3_beta, 53BP1, and JNK_pT183_Y185. Each is linked with RFC2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RFC2-to-partner and partner-to-RFC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RFC2-low versus RFC2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RFC2→partner) and Y-score (partner→RFC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.105	-2.973	.030	.035	3	2
UCEC	53BP1 →	+0.370	+2.459	.025	.020	3	2
UCEC	JNK_pT183_Y185 →	-0.215	-2.999	.008	.035	3	1
UCEC	Ku80 →	+0.365	+3.179	.001	.010	3	1
UCEC	4E-BP1 →	+0.336	+2.837	.010	.035	3	1
UCEC	Collagen-VI →	-0.249	-2.986	.012	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

14-3-3_beta by RFC2 expression — UCEC

Explore this box plot interactively →