RFC2

Across TCGA cell cohorts, RFC2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,678 significant associations in total. BONE shows the largest number of these associations.

The most reproducible RFC2-associated GO terms across cancer lineages are Positive regulation of DNA-templated DNA replication, Nuclear DNA replication, and DNA replication initiation. Each is linked with RFC2 in more than 17 cancer types. Because this analysis shows association rather than direction, both RFC2-to-partner and partner-to-RFC2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of DNA-templated DNA replication grouped by RFC2-low versus RFC2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RFC2→partner) and Y-score (partner→RFC2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Positive regulation of DNA-templated DNA replication →	+0.105	+0.758	<.001	<.001	3	18
BONE	Nuclear DNA replication →	+0.144	+0.980	<.001	<.001	3	18
OESOPHAGUS	DNA replication initiation →	+0.196	+1.241	<.001	<.001	3	18
BONE	Regulation of chromosome condensation →	+0.192	+0.985	<.001	.005	3	18
SOFT_TISSUE	Meiotic chromosome condensation →	+0.166	+0.953	<.001	<.001	3	17
BONE	Mitotic DNA replication →	+0.181	+1.146	.003	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,678 associations by consensus.

Positive regulation of DNA-templated DNA replication by RFC2 expression — KIDNEY

Explore this box plot interactively →