REST

Across TCGA pan-cancer cohorts, REST mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated REST data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher REST mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated REST expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

CCRCC, PDAC, and LUAD are the cancer types where REST mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	All	0.583	0.912	<.001	25	view →
PDAC	DFS	Quartile	All	0.228	0.629	.035	10	view →
LUAD	OS	Median	III,IV	0.807	0.430	.024	6	view →
LSCC	OS	Quartile	II,III,IV	1.000	0.680	.029	4	view →
HNSC	DFS	Quartile	II,III,IV	0.967	0.869	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

REST–CCRCC (DFS)

Open the CCRCC breakdown →