RESP18

Across TCGA patient cohorts, RESP18 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RESP18-associated genes across cancer lineages are 14-3-3_beta, Heregulin, and Annexin-1. Each is linked with RESP18 in more than 1 cancer types. Because this analysis shows association rather than direction, both RESP18-to-partner and partner-to-RESP18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by RESP18-low versus RESP18-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RESP18→partner) and Y-score (partner→RESP18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.120	-3.308	.022	.010	3	1
UCEC	Heregulin →	-0.188	-3.321	.003	.010	2	1
UCEC	Annexin-1 →	+0.713	+3.321	.009	.010	2	1
UCEC	Cyclin-B1 →	+0.641	+3.321	.029	.010	1	1
UCEC	Di-Ras3 →	-0.194	-3.321	.012	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

14-3-3_beta by RESP18 expression — UCEC

Explore this box plot interactively →