RERGL

Across TCGA patient cohorts, RERGL mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RERGL-associated genes across cancer lineages are Rab11, STAT3_pY705, and C-Raf. Each is linked with RERGL in more than 1 cancer types. Because this analysis shows association rather than direction, both RERGL-to-partner and partner-to-RERGL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rab11 grouped by RERGL-low versus RERGL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RERGL→partner) and Y-score (partner→RERGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab11 →	-0.168	-3.169	.035	.020	3	1
UCEC	STAT3_pY705 →	-0.642	-3.169	<.001	.018	3	1
UCEC	C-Raf →	+0.265	+3.169	<.001	.020	3	1
SKCM	eEF2 →	+0.282	+1.700	.042	.043	3	1
SKCM	14-3-3_epsilon →	+0.117	+1.717	.022	.026	3	1
SKCM	PEA-15 →	-0.167	-2.459	.012	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Rab11 by RERGL expression — UCEC

Explore this box plot interactively →