RERGL

Across TCGA pan-cancer cohorts, RERGL RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated RERGL data layer compared with 5 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher RERGL RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RERGL expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

ACC, BLCA, and KIRC are the cancer types where RERGL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Tertile	III,IV	0.227	0.714	.001	65	view →
BLCA	DFS	Tertile	All	0.256	0.490	<.001	64	view →
KIRC	DFS	Median	All	0.702	0.550	<.001	55	view →
LGG	DFS	Median	All	0.896	0.768	<.001	49	view →
LIHC	DFS	Tertile	All	0.529	0.336	<.001	36	view →
ESCA	DFS	Tertile	All	0.601	0.397	.006	25	view →
CESC	OS	Tertile	All	0.926	0.783	.002	24	view →
SKCM	OS	Median	II,III,IV	0.904	0.779	.006	24	view →
GBM	OS	Median	All	0.457	0.227	.004	21	view →
STAD	DFS	Median	IV	0.138	0.500	.028	18	view →
BRCA	OS	Tertile	III,IV	0.900	0.754	.003	17	view →
READ	DFS	Median	II,III,IV	0.879	0.726	.009	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

RERGL–ACC (OS)

Open the ACC breakdown →