RERGL

Across TCGA cell cohorts, RERGL mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible RERGL-associated genes across cancer lineages are CABP5, PPP3R2, and ADGRA1. Each is linked with RERGL in more than 1 cancer types. Because this analysis shows association rather than direction, both RERGL-to-partner and partner-to-RERGL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CABP5 grouped by RERGL-low versus RERGL-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RERGL→partner) and Y-score (partner→RERGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CABP5 →	+0.012	+4.437	<.001	.004	3	1
SKIN	PPP3R2 →	+0.017	+4.459	<.001	.003	3	1
SKIN	ADGRA1 →	+0.007	+4.510	<.001	.001	3	1
SKIN	KIR3DL3 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	ACOD1 →	+0.083	+3.632	<.001	.003	3	1
LARGE_INTESTINE	RTL3 →	+0.019	+3.347	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

CABP5 by RERGL expression — SKIN

Explore this box plot interactively →