RERG-IT1

Across TCGA pan-cancer cohorts, RERG-IT1 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated RERG-IT1 data layer.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher RERG-IT1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated RERG-IT1 expression acts as an unfavorable survival marker, although some lineages such as ACC and UCS show a favorable association.

ACC, UCS, and BRCA are the cancer types where RERG-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Tertile	II,III,IV	0.755	0.248	<.001	76	view →
UCS	OS	Tertile	II,III,IV	0.723	0.304	.007	74	view →
BRCA	OS	Median	II,III,IV	0.943	0.881	<.001	73	view →
UCEC	DFS	Quartile	All	0.854	0.909	.018	36	view →
LUAD	OS	Quartile	All	0.901	0.705	<.001	33	view →
LUSC	DFS	Median	II,III,IV	0.294	0.486	.007	13	view →
MESO	OS	Tertile	All	0.499	0.286	.019	6	view →
SKCM	OS	Tertile	All	0.867	0.766	.025	3	view →
CHOL	OS	Median	All	0.753	0.206	.036	3	view →
KIRP	DFS	Quartile	All	1.000	0.800	.036	2	view →
TGCT	OS	Median	All	0.922	1.000	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

RERG-IT1–ACC (DFS)

Open the ACC breakdown →