RERG-IT1

Across TCGA pan-cancer cohorts, RERG-IT1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RERG-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RERG-IT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RERG-IT1 is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

KIRC, BLCA, and COAD are the cancer types where RERG-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RERG-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.739	<.001	11	view →
BLCA	Male	IV	−1.162	<.001	8	view →
COAD	Male	II,III,IV	−0.653	<.001	8	view →
UCEC	All	All	−2.058	<.001	6	view →
LUSC	All	II,III,IV	−0.505	<.001	5	view →
KIRP	Male	III,IV	+0.499	.022	5	view →
LUAD	Female	II,III,IV	−0.635	.002	4	view →
STAD	All	II,III,IV	−0.568	.008	4	view →
BRCA	Female	All	−0.553	.001	4	view →
KICH	All	II,III,IV	+0.721	.005	3	view →
READ	All	All	−0.812	.002	2	view →
CHOL	All	All	+0.805	.021	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RERG-IT1–KIRC

Open the KIRC breakdown →