RERG-AS1

Across TCGA pan-cancer cohorts, RERG-AS1 RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated RERG-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RERG-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated RERG-AS1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and LGG show a favorable association.

KIRC, READ, and COAD are the cancer types where RERG-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.715	0.522	<.001	84	view →
READ	OS	Tertile	II,III,IV	0.691	0.926	.003	63	view →
COAD	DFS	Tertile	III,IV	0.147	0.704	<.001	45	view →
CESC	OS	Tertile	IV	0.121	0.591	.029	36	view →
LGG	DFS	Median	All	0.523	0.290	<.001	36	view →
BRCA	DFS	Tertile	III,IV	0.955	0.815	.001	34	view →
MESO	OS	Quartile	All	0.587	0.306	.008	20	view →
ESCA	DFS	Median	IV	0.213	0.626	.026	18	view →
KIRP	OS	Median	All	0.910	0.978	.005	12	view →
UCEC	DFS	Tertile	All	0.735	0.846	.011	12	view →
KICH	OS	Quartile	III,IV	0.885	0.242	.017	10	view →
UCS	OS	Median	II,III,IV	0.758	0.467	.027	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

RERG-AS1–KIRC (OS)

Open the KIRC breakdown →