RERE

Across TCGA patient cohorts, RERE mutation is significantly associated with the RNA expression of many other genes, with 3,948 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RERE-associated genes across cancer lineages are RCC1, PPIL4, and EIF2S1. Each is linked with RERE in more than 4 cancer types. Because this analysis shows association rather than direction, both RERE-to-partner and partner-to-RERE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RCC1 grouped by RERE-low versus RERE-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RERE→partner) and Y-score (partner→RERE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RCC1 →	+0.580	+2.932	<.001	<.001	3	5
COAD	PPIL4 →	+0.527	+3.700	.007	.001	3	4
STAD	EIF2S1 →	+0.545	+3.186	<.001	.009	3	4
SKCM	UTP11 →	+0.486	+2.373	<.001	.002	3	4
STAD	FAM136A →	+0.516	+3.509	.002	.002	3	4
STAD	PPP2R5C →	+0.572	+3.526	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,948 associations by consensus.

RCC1 by RERE expression — SKCM

Explore this box plot interactively →