RER1

Across TCGA patient cohorts, RER1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RER1-associated genes across cancer lineages are ERK2, ACC1, and JNK2. Each is linked with RER1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RER1-to-partner and partner-to-RER1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by RER1-low versus RER1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RER1→partner) and Y-score (partner→RER1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.270	+3.169	.005	.019	3	1
UCEC	ACC1 →	+0.424	+2.820	.020	.035	3	1
UCEC	JNK2 →	+0.263	+3.459	.008	.005	3	1
UCEC	4E-BP1_pT37_T46 →	-0.406	-2.321	.031	.035	3	1
UCEC	Chk2 →	-0.317	-3.459	.006	.005	3	1
UCEC	EGFR_pY1068 →	-0.382	-3.459	.002	.005	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ERK2 by RER1 expression — UCEC

Explore this box plot interactively →