RER1

Across TCGA pan-cancer cohorts, RER1 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated RER1 data layer compared with 1 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher RER1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RER1 expression acts as an unfavorable survival marker, although some lineages such as CHOL and LUAD show a favorable association.

ACC, KICH, and LGG are the cancer types where RER1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.265	0.631	<.001	116	view →
KICH	DFS	Tertile	III,IV	0.160	0.942	<.001	84	view →
LGG	DFS	Median	All	0.624	0.863	<.001	54	view →
HNSC	DFS	Median	All	0.578	0.736	.003	53	view →
CESC	DFS	Tertile	All	0.659	0.850	<.001	42	view →
CHOL	DFS	Median	All	0.744	0.106	<.001	38	view →
UVM	DFS	Median	All	0.400	0.736	.004	30	view →
LAML	DFS	Median	All	0.260	0.465	.007	24	view →
PAAD	OS	Quartile	All	0.263	0.545	.002	23	view →
LIHC	DFS	Median	All	0.369	0.508	.011	16	view →
BLCA	DFS	Tertile	All	0.468	0.678	.028	15	view →
LUSC	DFS	Quartile	III,IV	0.178	0.478	.026	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

RER1–ACC (DFS)

Open the ACC breakdown →