REP15

Across TCGA patient cohorts, REP15 mutation is significantly associated with the RNA expression of many other genes, with 1,372 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REP15-associated genes across cancer lineages are MIR4457, BORCS7-ASMT, and FAM27B. Each is linked with REP15 in more than 1 cancer types. Because this analysis shows association rather than direction, both REP15-to-partner and partner-to-REP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4457 grouped by REP15-low versus REP15-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REP15→partner) and Y-score (partner→REP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR4457 →	+0.947	+5.279	<.001	.006	3	1
LUAD	BORCS7-ASMT →	+0.164	+5.157	<.001	.007	3	1
UCEC	FAM27B →	+0.086	+3.579	<.001	.002	3	1
UCEC	LINC01727 →	+0.067	+2.840	.007	<.001	3	1
COAD	RNU6-1127P →	+0.390	+5.136	<.001	.002	3	1
COAD	SNORD116-19 →	+0.630	+3.792	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,372 associations by consensus.

MIR4457 by REP15 expression — LUAD

Explore this box plot interactively →