REM2

Across TCGA patient cohorts, REM2 mutation is significantly associated with the RNA expression of many other genes, with 1,033 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REM2-associated genes across cancer lineages are RPL12P3, OR1E3, and MIR133B. Each is linked with REM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both REM2-to-partner and partner-to-REM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPL12P3 grouped by REM2-low versus REM2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REM2→partner) and Y-score (partner→REM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RPL12P3 →	+0.212	+5.136	<.001	.002	3	2
LUAD	OR1E3 →	+0.119	+5.554	<.001	.004	3	2
LUSC	MIR133B →	+0.409	+7.924	<.001	.008	3	2
SKCM	MIR4505 →	+0.426	+3.408	<.001	.009	3	2
SKCM	ZFRP1 →	+0.009	+4.624	<.001	.005	3	1
COAD	OR56A5 →	+0.078	+4.081	.004	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,033 associations by consensus.

RPL12P3 by REM2 expression — COAD

Explore this box plot interactively →