REM2

Across TCGA pan-cancer cohorts, REM2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of REM2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where REM2 RNA is repressed in tumor relative to normal tissue. In most cancer types REM2 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

KICH, COAD, and KIRC are the cancer types where REM2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in REM2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Male	All	−0.715	<.001	11	view →
COAD	Male	II,III,IV	+0.778	<.001	10	view →
KIRC	Male	II,III,IV	−0.253	<.001	7	view →
UCEC	All	All	+1.183	<.001	6	view →
BRCA	All	III,IV	+0.678	<.001	6	view →
READ	All	All	+0.835	.001	3	view →
STAD	All	All	+0.266	.034	3	view →
HNSC	Male	All	+0.200	.018	3	view →
CHOL	Male	All	+0.870	<.001	2	view →
BLCA	All	All	+0.533	.023	2	view →
LUAD	Female	All	+0.259	.006	2	view →
LUSC	All	All	+0.206	.012	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

REM2–KICH

Open the KICH breakdown →