REM2

Across TCGA patient cohorts, REM2 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible REM2-associated genes across cancer lineages are EGFR_pY1068, MAPK_pT202_Y204, and Notch1. Each is linked with REM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both REM2-to-partner and partner-to-REM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by REM2-low versus REM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (REM2→partner) and Y-score (partner→REM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.374	-3.459	.002	.005	3	1
UCEC	MAPK_pT202_Y204 →	-0.554	-3.169	.018	.019	3	1
UCEC	Notch1 →	+0.146	+3.013	.039	.018	3	1
UCEC	Shc_pY317 →	-0.242	-3.000	.001	.036	3	1
UCEC	STAT3_pY705 →	-0.451	-2.321	<.001	.035	3	1
UCEC	ATM →	-0.618	-2.321	.006	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

EGFR_pY1068 by REM2 expression — UCEC

Explore this box plot interactively →