RELL1

Across TCGA patient cohorts, RELL1 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RELL1-associated genes across cancer lineages are RN7SKP181, RNU6-582P, and SNORD115-30. Each is linked with RELL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both RELL1-to-partner and partner-to-RELL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP181 grouped by RELL1-low versus RELL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RELL1→partner) and Y-score (partner→RELL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP181 →	+0.192	+3.133	<.001	.009	3	2
BRCA	RNU6-582P →	+0.361	+8.471	<.001	.005	3	1
BRCA	SNORD115-30 →	+0.448	+8.471	<.001	.005	3	1
BRCA	RNU6-499P →	+0.304	+8.471	<.001	.005	3	1
BRCA	KRTAP9-11P →	+0.089	+8.471	<.001	.005	3	1
BRCA	ELOCP7 →	+0.139	+8.055	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

RN7SKP181 by RELL1 expression — UCEC

Explore this box plot interactively →