REG4

Across TCGA patient cohorts, REG4 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,984 significant associations in total. TGCT shows the largest number of these associations.

The most reproducible REG4-associated GO terms across cancer lineages are Intracellular monoatomic anion homeostasis, Phosphatidylcholine metabolic process, and Central nervous system myelin maintenance. Each is linked with REG4 in more than 10 cancer types. Because this analysis shows association rather than direction, both REG4-to-partner and partner-to-REG4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Intracellular monoatomic anion homeostasis grouped by REG4-low versus REG4-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (REG4→partner) and Y-score (partner→REG4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Intracellular monoatomic anion homeostasis →	+0.146	+4.935	<.001	<.001	3	11
ESCA	Phosphatidylcholine metabolic process →	+0.045	+3.408	<.001	<.001	2	11
ESCA	Central nervous system myelin maintenance →	+0.183	+4.885	<.001	<.001	3	10
ESCA	Epithelial structure maintenance →	+0.086	+5.016	<.001	<.001	3	10
ESCA	Calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules →	+0.122	+4.142	<.001	<.001	3	10
ESCA	Digestive system process →	+0.087	+5.620	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,984 associations by consensus.

Intracellular monoatomic anion homeostasis by REG4 expression — ESCA

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