REG4

Across TCGA pan-cancer cohorts, REG4 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated REG4 data layer compared with 5 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher REG4 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated REG4 expression acts as an unfavorable survival marker, although some lineages such as BRCA and BLCA show a favorable association.

KIRP, BRCA, and BLCA are the cancer types where REG4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.345	0.725	<.001	64	view →
BRCA	DFS	Tertile	II,III,IV	0.593	0.475	.007	63	view →
BLCA	OS	Quartile	II,III,IV	0.608	0.340	.003	47	view →
HNSC	DFS	Tertile	All	0.744	0.624	.005	47	view →
UVM	OS	Tertile	All	0.669	0.946	.010	45	view →
SKCM	DFS	Median	All	0.801	0.681	<.001	39	view →
STAD	DFS	Median	II,III,IV	0.599	0.768	.018	35	view →
COAD	OS	Median	All	0.879	0.726	.003	33	view →
ESCA	DFS	Median	All	0.447	0.926	.004	27	view →
PRAD	DFS	Tertile	All	0.823	0.676	<.001	16	view →
LGG	DFS	Quartile	All	0.884	0.729	<.001	15	view →
LAML	DFS	Tertile	All	0.359	0.637	.026	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

REG4–KIRP (DFS)

Open the KIRP breakdown →